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KMID : 0366220080430030174
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Korean Journal of Hematology
2008 Volume.43 No. 3 p.174 ~ p.178
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A Case of Epstein-Barr Virus-positive Diffuse, Large B-cell Lymphoma after Angioimmunoblastic T-cell Lymphoma
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Choi Yoon-Hee
Kim Hyo-Seok
Nam Seung-Bum
Kang Hye-Jin
Na Im-II
Yang Sung-Hyun
Ryoo Baek-Yeol
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Abstract
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Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disorder that presents with profound immune dysfunction and immunodeficiency. As in many other immunodeficiencies, Epstein-Barr virus (EBV) associated B-cell lymphoid proliferation can occur in AITL but few cases of EBV-positive B-cell lymphoma have been reported in patients with preexisting AITL. We report a case of AITL in which EBV-positive diffuse large B-cell lymphoma (DLBCL) developed 13 months after the initial diagnosis of AITL. Although the exact mechanisms remain unclear, Epstein-Barr virus may have played a role in the pathogenesis of the secondary DLBCL.
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KEYWORD
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Angioimmunoblastic T-cell lymphoma, Diffuse large B-cell lymphoma, Epstein-Barr virus
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